Mechanistic aspects and spatial effects in cell signalling


within TEAM Programme sponsored by Foundation for Polish Science


Concepts and objectives


The leading aim of the project is to identify and study the turning points in molecular pathways of immune response and cancer, in which the single cell fate, understood as a choice between apoptosis, senescence, proliferation, differentiation or cell cycle arrest, is decided. As a model molecular pathways we will consider these related to innate and adaptive immune response and cancer, in which we have expertise. The project will be realized both by means of numerical simulations and theoretical analysis.

TEAM project laureates:

Postdoc:
Piotr Szopa, Ph.D.

Ph.D. Students:
Michal Dyzma, M.Sc.
Joanna Jaruszewicz, M.Sc.
Pawel Kocieniewski, M.Sc.

Undergraduate Students:
Jakub Pekalski
Pawel Zuk


Team members:

Tomasz Lipniacki - principal investigator (Institute of Fundamental Technological Research, PAS, Warsaw, Poland)

Bogdan Kazmierczak (Institute of Fundamental Technological Research, PAS, Warsaw, Poland)

Aleksandra Nowicka (Institute of Theoretical Physics, PAS, Warsaw, Poland)

Beata Hat-Plewinska (Institute of Fundamental Technological Research, PAS, Warsaw, Poland).


External collaborators:

Prof. Mark Alber (Notre Dame University, US),

Prof. Allan R. Brasier (UTMB Galveston, TX, US),

Assoc. Prof. James R. Faeder (University of Pittsburgh School of Medicine, US),

Assoc. Prof. William S. Hlavacek (Los Alamos National Laboratories, US),

Prof. Marek Kimmel (Rice University and MD Anderson Cancer Center, Houston, TX, US),

Prof. Vitaly Volpert (Universite Claude Bernard - Lyon 1, France),

Prof. Michael R.H. White (Liverpool University, UK).